HOW IT WORKS
Fast, Accurate and Fully Automated Subvisible Particle Analysis for 96 Samples in Under 2 Hours.
The Horizon® and Aura™ instrument’s primary analytical technique is Backgrounded Membrane Imaging (BMI). BMI has its roots in membrane microscopy, the old USP 788 subvisible particle lot release method where samples are filtered through a membrane and captured particles are manually counted using a microscope.
BMI reinvents membrane imaging with modern robotics, image processing and novel optics in a 96 well filter plate format that works just like a plate reader.
|BMI||Light Obscuration||Flow Imaging|
|Low Volume Requirements||Requires 5 µL – 100X less than competition.||Requires 5 mL||Requires 500 µL|
|Highly Reproducible||CVs of polydisperse samples under 6%.||Highly variable on polydisperse samples.||Highly variable on polydisperse samples.|
|Consumable||ZERO particle carry over, ZERO cross contamination and ZERO washing.||Multiple components that require washing.||Expensive flow cell that requires washing.|
|High Refractive Index Contrast (High Sensitivity)||Dry based measurment = analyze small and dim particles with higher fidelity.||Low contrast, liquid based measurement.||Low contrast, liquid based measurement.|
|Fluidics Free||ZERO purge volume, ZERO leaking, ZERO clogging.||Fluidics-based.||Fluidics-based.|
|No Confounding “Particles”||Air bubbles are not measured..||Air bubbles counted as particles.||Air bubbles counted as particles.|
|Instrument Compatibility||Particles on membrane can be analyzed later with other instruments.||Sample ends up in waste, no additional analysis possible.||Sample ends up in waste, no additional analysis possible.|