HOW IT WORKS
Fast, accurate and fully automated subvisible particle analysis for 96 samples in under 2 hours.
The HORIZON instrument’s primary analytical technique is Backgrounded Membrane Imaging (BMI). BMI has its roots in membrane microscopy, the old USP 788 subvisible particle lot release method where samples are filtered through a membrane and captured particles are manually counted using a microscope.
BMI reinvents membrane imaging with modern robotics, image processing and novel optics in a 96 well filter plate format that works just like a plate reader.
|BMI||Light Obscuration||Flow Imaging|
|Low Volume Requirements||Requires 25 µL – 20X less than competition.||Requires 5 mL||Requires 500 µL|
|Highly Reproducible||CVs of polydisperse samples under 6%.||Highly variable on polydisperse samples.||Highly variable on polydisperse samples.|
|Consumable||ZERO particle carry over, ZERO cross contamination and ZERO washing.||Multiple components that require washing.||Expensive flow cell that requires washing.|
|High Refractive Index Contrast||Dry based measurment = analyze small and dim particles with higher fidelity.||Low contrast, liquid based measurement.||Low contrast, liquid based measurement.|
|Fluidics Free||ZERO purge volume, ZERO leaking, ZERO clogging.||Fluidics-based.||Fluidics-based.|
|No Confounding “Particles”||Air bubbles are not measured..||Air bubbles counted as particles.||Air bubbles counted as particles.|
|Instrument Compatibility||Particles on membrane can be analyzed later with other instruments.||Sample ends up in waste, no additional analysis possible.||Sample ends up in waste, no additional analysis possible.|