Upcoming and Recorded Webinars
Bioprocess International Ask the Expert: Protein or Not? Advanced High-Throughput Aggregate Analysis with the Aura
Thursday, June 25, 2020 8:00 am (PT)
In protein-based formulations, distinguishing aggregated active pharmaceutical ingredient (API) from other particle types is important for understanding the root cause of instability. Until now, existing methods have been either unreliable or too cumbersome to use in many workflows.
Here we introduce the Aura™ 96-well low-volume aggregate and particle imaging system, which can rapidly size, count, and characterize particles and identify them as proteins, non-proteins, hydrophobic, or other types of molecules.
Protein or Not? Advanced High Throughput Aggregate Analysis with the Aura
Wednesday, June 10, 2020 9:00 AM PT
In protein-based formulations, distinguishing aggregated API from other particle types is important for understanding the root cause of instability. Until now, existing methods have been either unreliable or too cumbersome and difficult to use in many workflows. Here we introduce the Aura, a 96-well low-volume aggregate and particle imaging system that can rapidly size, count, and characterize particles and identify them as proteins, non-proteins, hydrophobic, or other types of molecules.
Are You Seeing the Whole Picture? Backgrounded Membrane Imaging (BMI) as a Multi-Use Analytical Tool for Developability Assessment through Late State Formulation
Tuesday, May 12, 2020 8:00 am (PT)
Subvisible particles (SVPs) are a key quality attribute of protein therapeutics and an indicator of drug efficacy and safety. Yet commonly used methods for characterizing SVPs such as light obscuration and flow imaging are limited by high volume consumption, long measurement times, and difficulty handling viscous, high concentration samples. Here we introduce Backgrounded Membrane Imaging (BMI), a fully automated form of USP <788> membrane microscopy available on the Horizon instrument from Halo Labs. BMI utilizes disposable 96-well membrane plates and automated image processing to rapidly generate accurate particle counts and sizing in low volume, high throughput format. With BMI, subvisible aggregate analysis can be incorporated at any stage of biologic development – from candidate selection to formulation screening, process development, and analytical – providing key insights that reduce drug development risk and time to market.
AAV Vector Stability with BMI – Are Your Analytics Giving You the Whole Picture?
Wednesday, April 29, 2020 9:00 am (PT)
Subvisible particle (SVP) analysis in parenteral formulations is a key predictor of safety and efficacy, and an essential drug quality metric. For viral vectors, however, limited availability of sample makes measuring SVP’s a challenge. Standard methods such as light obscuration and flow imaging are impractical due to their large volume requirements and low throughput.
This seminar will introduce automated Backgrounded Membrane Imaging (BMI) as a solution for detecting and quantifying subvisible AAV aggregates in low volume, high throughput format. BMI is fully automated, fluidics-free, and uses only 25 μL per sample. Learn how BMI’s high-resolution images and comprehensive data analysis can reveal particle issues that may be missed by other methods like DLS and SEC – providing a more complete picture of your viral vector stability
Rapid, Low Volume Subvisible Particle Analysis with HORIZON
Wednesday, March 26, 2020 9:30 am (PT)
Subvisible particle analysis is a key predictor of protein drug stability and an essential drug product quality metric. However, current subvisible methods require large volumes of precious samples and are labor- and time-intensive, making it challenging to obtain this vital information during late-stage candidate screening and early development — especially with high concentration protein formulations. The HORIZON® system from Halo Labs is the industry’s first analytical system to address the need for rapid, comprehensive subvisible particle analysis even when limited sample material is available.
New Horizons In Small Molecule Solubility Screening
Thursday, November 21, 2019 3:00 PM (GMT)
In this webinar, you will learn how about Backgrounded Membrane Imaging (BMI) on the HORIZON system can accelerate discovery and early ADME workflows as an easy and sensitive method for compound solubility measurement. In addition, highly resolved images and shape distribution data provide valuable information on morphology of precipitated solids for more comprehensive solubility characterization.
Seeking the Unseen: Sub-Visible Particle Analysis as a Core Analytical Technique
Tuesday, June 11, 2019 11:00 am EDT
In this webinar, Fujifilm Diosynth Biotechnologies presents comparative analytical data spanning across several different research programs and also present a more detailed story about a particular monoclonal antibody for which they have recently completed accelerated and real-time stability studies.
High Throughput Low Volume Subvisible Analysis – GEN Webinar
Recorded February, 2018
Watch the latest GEN webinar where we will learn how a the new particle analysis instrument HORIZON employs backgrounded membrane imaging (BMI) to measure subvisible particles accurately and rapidly at low volumes.